Therapeutic peptide vaccines for treatment of autoimmune diseases

Immunol Lett. 2009 Feb 21;122(2):134-6. doi: 10.1016/j.imlet.2008.11.013. Epub 2008 Dec 25.

Abstract

Recent advances in immunology have led to exciting new possibilities in medicine. We now understand how to design vaccine capable of resetting the balance between immune effector and regulatory cells in people suffering from autoimmune and allergic diseases. These approaches are effective while avoiding the side effects associated with non-specific immune suppression.

Publication types

  • Review

MeSH terms

  • Allergens / immunology
  • Anaphylaxis / prevention & control
  • Animals
  • Antigen Presentation
  • Autoantigens / immunology*
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy
  • Cytokines / immunology
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Dendritic Cells / pathology
  • Desensitization, Immunologic
  • Homeostasis
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / pathology
  • Hypersensitivity / therapy
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocyte Subsets / pathology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism
  • T-Lymphocytes, Regulatory / pathology
  • Vaccines, Subunit / immunology*
  • Vaccines, Subunit / therapeutic use

Substances

  • Allergens
  • Autoantigens
  • Cytokines
  • Vaccines, Subunit