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Immunity. 2008 Dec 19;29(6):845-7. doi: 10.1016/j.immuni.2008.12.002.

Elite suppression of HIV-1 replication.

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1
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Rare HIV-1-infected individuals are able to control viral replication without antiretroviral therapy. In this issue of Immunity, Migueles et al. (2008) show that HIV-1-specific CD8+ T cells from these individuals effectively suppress viral replication by granzyme B-mediated killing of target cells.

PMID:
19100698
DOI:
10.1016/j.immuni.2008.12.002
[Indexed for MEDLINE]
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