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Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Mar;36(3):219-22.

[Circulating cytokine measurements by protein chips in patients with acute coronary syndrome].

[Article in Chinese]

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Department of Cardiology, First People's Hospital, Guiyang 550002, China.



To observe the feasibility of measuring multiple circulating cytokines by protein chips in patients with acute coronary syndrome (ACS).


Circulating cytokines were determined by protein chips in 50 control cases and 104 ACS cases of unstable angina pectoris (UA, n = 50) and acute myocardial infarction (AMI, n = 54) cases.


The levels of serum MMP-9, sCD40L, CRP, IL-6, H-FABP, cTnI and plasma IL-8, NT-proBNP, sVCAM-1, ET-1 in ACS group were significantly higher than those in the control group (all P < 0.01). Serum H-FABP and cTnI were significantly higher in AMI patients than in UA patients (P < 0.01). Serum MMP-9, sCD40L, CRP, IL-6 and plasma sVCAM-1, ET-1 tended to be higher in AMI patients as compared to UA patients (all P > 0.05). Serum MMP-9, sCD40L, and H-FABP were positively correlated with the severity of angina(r = 0.653, r = 0.745, r = 0.933, P < 0.01, respectively). Serum MMP-9, sCD40L, and H-FABP increased in proportion to the levels of Braunwald angina classes in UA patients (angina class I < angina class II < angina class III, P < 0.01).


Circulating cytokines were significantly increased in ACS patients and positively correlated to Braunwald angina classes in UA patients.

[Indexed for MEDLINE]

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