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Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Mar;36(3):219-22.

[Circulating cytokine measurements by protein chips in patients with acute coronary syndrome].

[Article in Chinese]

Author information

1
Department of Cardiology, First People's Hospital, Guiyang 550002, China. maobaosisiley@yahoo.com.cn

Abstract

OBJECTIVE:

To observe the feasibility of measuring multiple circulating cytokines by protein chips in patients with acute coronary syndrome (ACS).

METHODS:

Circulating cytokines were determined by protein chips in 50 control cases and 104 ACS cases of unstable angina pectoris (UA, n = 50) and acute myocardial infarction (AMI, n = 54) cases.

RESULTS:

The levels of serum MMP-9, sCD40L, CRP, IL-6, H-FABP, cTnI and plasma IL-8, NT-proBNP, sVCAM-1, ET-1 in ACS group were significantly higher than those in the control group (all P < 0.01). Serum H-FABP and cTnI were significantly higher in AMI patients than in UA patients (P < 0.01). Serum MMP-9, sCD40L, CRP, IL-6 and plasma sVCAM-1, ET-1 tended to be higher in AMI patients as compared to UA patients (all P > 0.05). Serum MMP-9, sCD40L, and H-FABP were positively correlated with the severity of angina(r = 0.653, r = 0.745, r = 0.933, P < 0.01, respectively). Serum MMP-9, sCD40L, and H-FABP increased in proportion to the levels of Braunwald angina classes in UA patients (angina class I < angina class II < angina class III, P < 0.01).

CONCLUSIONS:

Circulating cytokines were significantly increased in ACS patients and positively correlated to Braunwald angina classes in UA patients.

PMID:
19099977
[Indexed for MEDLINE]

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