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Arch Pharm Res. 2008 Dec;31(12):1547-51. doi: 10.1007/s12272-001-2149-3. Epub 2008 Dec 20.

Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia.

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1
Key Laboratory of Marine Drugs, Ministry of Education, Qingdao, China.

Abstract

A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 microM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.

PMID:
19099222
DOI:
10.1007/s12272-001-2149-3
[Indexed for MEDLINE]
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