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Exerc Sport Sci Rev. 2009 Jan;37(1):18-22. doi: 10.1097/JES.0b013e318190ebdb.

Dual and beneficial roles of macrophages during skeletal muscle regeneration.

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1
Institut COCHIN INSERM U567 CNRS UMR8104, Paris, France. benedicte.chazaud@inserm.fr

Abstract

Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.

PMID:
19098520
DOI:
10.1097/JES.0b013e318190ebdb
[Indexed for MEDLINE]
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