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Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1483-91. doi: 10.1167/iovs.08-2595. Epub 2008 Dec 20.

Predicting visual sensitivity in retinal prosthesis patients.

Author information

1
Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA. horsager@usc.edu

Abstract

PURPOSE:

With the long-term goal of restoring functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects were implanted chronically with epiretinal prostheses consisting of two-dimensional electrode arrays that directly stimulated cells of the neural retina.

METHODS:

Psychophysical techniques were used to measure the brightness of electrically generated percepts on single electrodes using a variety of electrical stimulation patterns.

RESULTS:

It was possible to predict the sensitivity of the human visual system to a wide variety of retinal electrical stimulation patterns using a simple and biologically plausible model.

CONCLUSIONS:

This is the first study to demonstrate that, on the single-electrode level, retinal electrical stimulation in humans can produce visual qualia that are predictable using a quantitative model, a prerequisite for a successful retinal prosthesis. (ClinicalTrials.gov number, NCT00279500.).

PMID:
19098313
PMCID:
PMC2729061
DOI:
10.1167/iovs.08-2595
[Indexed for MEDLINE]
Free PMC Article

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