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Mol Genet Metab. 2009 Mar;96(3):145-7. doi: 10.1016/j.ymgme.2008.11.161. Epub 2008 Dec 18.

A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.

Author information

1
Department of Advanced Medical Science, Division of Molecular Diagnostics, Nihon University School of Medicine, Tokyo, Japan.

Abstract

This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).

PMID:
19097922
DOI:
10.1016/j.ymgme.2008.11.161
[Indexed for MEDLINE]

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