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Arch Gynecol Obstet. 2009 Jul;280(1):79-85. doi: 10.1007/s00404-008-0876-0. Epub 2008 Dec 19.

Prognosticators and the role of lymphadenectomy in uterine leiomyosarcomas.

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1
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Baskent University School of Medicine, Tandogan, Ankara, Turkey.

Abstract

OBJECTIVE:

To analyze prognostic factors, the role of lymphadenectomy and postoperative adjuvant treatments in patients with uterine leiomyosarcomas (LMS).

STUDY DESIGN:

Sixty-three patients with uterine LMS are retrospectively analyzed with respect to both DFS and OS.

RESULTS:

Multivariate DFS analysis revealed percentage necrosis to be the unique factor to be significant (median DFS was 3.31 years for <25% necrosis and 0.78 for >25% necrosis). Multivariate analysis revealed the mitotic counts to be the unique significant factor affecting the OS (median OS was 7.20 and 1.73 years, respectively, for patients with mitotic counts of 1-5 and >6; respectively). Median DFS was 2.51 years for patients who had undergone lymphadenectomy and 2.36 years for remaining who did not have a lymphadenectomy procedure (P = 0.4). With respect to OS, median values were 2.44 and 3.16 years, respectively (P = 0.7). Number of the resected lymph nodes was also not significant for both OS and DFS.

CONCLUSIONS:

Mitotic counts and percentage necrosis have significant effects on OS and DFS; respectively. Neither the performance nor the extent of lymphadenectomy has an effect on patient survival.

PMID:
19096861
DOI:
10.1007/s00404-008-0876-0
[Indexed for MEDLINE]
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