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Biofactors. 2008;32(1-4):245-55.

Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.

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R&D, Beiersdorf AG, Hamburg, Germany.


The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age-dependent differences in mitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly non-mitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.

[Indexed for MEDLINE]

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