Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Cancer. 2009 Mar;45(5):843-50. doi: 10.1016/j.ejca.2008.11.001. Epub 2008 Dec 16.

Wine, liquor, beer and risk of breast cancer in a large population.

Author information

1
Oncology Department, Kaiser Permanente Medical Center, Oakland, CA 94611, USA.

Abstract

Population studies show a relation of alcohol drinking to an increased risk of breast cancer (BrCa). Aiming to investigate uncertainties about a risk threshold, the role of beverage type and interactions with other BrCa predictors, we performed a cohort study among 70,033 women, 2,829 of whom developed BrCa. Using Cox proportional hazards models with 8 covariates, the following relative risks (95% confidence intervals) for BrCa versus lifelong abstainers were found: 1.08 (0.95-1.22) at <1 drink per day, 1.21 (1.05-1.40, p=0.01) at 1-2 drinks daily and 1.38 (1.13-1.68, p=0.002) at > or = 3 drinks daily. Increased BrCa risk was concentrated in women with oestrogen receptor positive tumours with no major disparity related to choice of wine, liquor, beer or type of wine (red, white, etc). We conclude that with a threshold below 1-2 drinks daily, a hormone-related mechanism mediates a relation of alcohol drinking to an increased BrCa risk.

PMID:
19095438
DOI:
10.1016/j.ejca.2008.11.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center