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Am J Surg. 2009 Jul;198(1):46-50. doi: 10.1016/j.amjsurg.2008.05.006. Epub 2008 Dec 17.

Accurate axillary lymph node dissection is feasible after neoadjuvant chemotherapy.

Author information

1
Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. m.straver@nki.nl

Abstract

BACKGROUND:

Recently, lower axillary lymph node retrieval after neoadjuvant chemotherapy was reported. We did not have this experience, and retrospectively analyzed our axillary lymph node dissections (ALNDs).

METHODS:

One hundred ninety-one patients who had ALND after neoadjuvant chemotherapy were compared with 192 patients with primary ALND after a positive sentinel node biopsy.

RESULTS:

There were no differences in the mean number of nodes retrieved between the neoadjuvant group and the primary surgery group: 16.3 (range 4-38) and 15.8 (range 6-33), respectively (P = .4); or in the retrieval of fewer than 10 lymph nodes: 13/191 (7%) and 11/192 (6%) (P = .7). The number of cases with retrieval of more than 20 lymph nodes was higher in the neoadjuvant group: 42/191 (22%) versus 26/192 (13%) (P = .03). In the neoadjuvant group, 150/191 (79%) patients had residual lymph node metastasis after neoadjuvant chemotherapy.

CONCLUSION:

Our results show the feasibility and need to remove enough lymph nodes to provide precise prognostic information and adequate local control.

PMID:
19095215
DOI:
10.1016/j.amjsurg.2008.05.006
[Indexed for MEDLINE]
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