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Microbiol Immunol. 1991;35(2):163-6.

Practical methods for chemical inactivation of Creutzfeldt-Jakob disease pathogen.

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  • 1Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka.


Chemical inactivation of pathogen of Creutzfeldt-Jakob disease (CJD) was examined using the mouse-adapted CJD strain. A high concentration of formic acid, guanidine compounds, trichloroacetate and phenol prevented CJD transmission. NaOH between 0.25 and 2 N lengthened the incubation periods. Sodium dodecyl sulfate (SDS) in a concentration between 1 and 3% did not alter incubation at room temperature but did completely block the transmission after boiling for 3 min in 3% SDS. This method is recommended for practical disinfection.

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