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Clin Pharmacol Ther. 2009 Jan;85(1):20-2. doi: 10.1038/clpt.2008.209.

Safety issues of maternal drug therapy during breastfeeding.

Author information

1
Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA. cmb6@psu.edu

Abstract

Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case-control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose-response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.

PMID:
19092767
DOI:
10.1038/clpt.2008.209
[Indexed for MEDLINE]

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