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Spine (Phila Pa 1976). 2008 Dec 15;33(26):2898-908. doi: 10.1097/BRS.0b013e3181891751.

The pathogenesis of adolescent idiopathic scoliosis: review of the literature.

Author information

1
Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

STUDY DESIGN:

Review of the literature on the pathogenesis of adolescent idiopathic scoliosis (AIS).

OBJECTIVE:

To discuss the different theories that have appeared on this subject.

SUMMARY OF BACKGROUND DATA:

The pathogenesis of AIS, a condition exclusive to humans, has been the subject of many studies. Over the years, practically every structure of the body has been mentioned in the pathogenesis of AIS; however, the cause of this spinal deformity remains little understood. The pathogenesis of this condition is termed multifactorial.

METHODS:

PubMed and Google Scholar electronic databases were searched focused on parameters concerning the pathogenesis of adolescent idiopathic scoliosis. The search was limited to the English language.

RESULTS:

No single causative factor for the development of idiopathic scoliosis has been identified, it is thus termed multifactorial. AIS is a complex genetic disorder. The fully erect posture, which is unique to humans, seems to be a prerequisite for the development of AIS.

CONCLUSION:

Although any or all of the mentioned factors in this review may play a certain role in the initiation and progression of AIS at a certain stage, the presented material suggests that in the observed deformation, genetics, and the unique mechanics of the fully upright human spine play a decisive role.

PMID:
19092622
DOI:
10.1097/BRS.0b013e3181891751
[Indexed for MEDLINE]

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