Abstract
Separation of the cortical sheet into functionally distinct regions is a hallmark of neocortical organization. Cortical circuit function emerges from afferent and efferent connectivity, local connectivity within the cortical microcircuit, and the intrinsic membrane properties of neurons that comprise the circuit. While localization of functions to particular cortical areas can be partially accounted for by regional differences in both long range and local connectivity, it is unknown whether the intrinsic membrane properties of cortical cell types differ between cortical regions. Here we report the first example of a region-specific firing type in layer 5 pyramidal neurons, and show that the intrinsic membrane and integrative properties of a discrete subtype of layer 5 pyramidal neurons differ between primary motor and somatosensory cortices due to region- and cell-type-specific Kv1 subunit expression.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Action Potentials / drug effects
-
Action Potentials / physiology*
-
Animals
-
Elapid Venoms / pharmacology
-
Electric Stimulation
-
Genes, Reporter
-
Luminescent Proteins / biosynthesis
-
Luminescent Proteins / genetics
-
Memory, Short-Term / physiology
-
Mice
-
Mice, Transgenic
-
Motor Cortex / cytology
-
Motor Cortex / drug effects
-
Motor Cortex / physiology*
-
Organ Culture Techniques
-
Patch-Clamp Techniques
-
Protein Subunits / drug effects
-
Protein Subunits / metabolism
-
Pyramidal Cells / drug effects
-
Pyramidal Cells / physiology*
-
Pyramidal Tracts / cytology
-
Pyramidal Tracts / physiology*
-
Shaker Superfamily of Potassium Channels / drug effects
-
Shaker Superfamily of Potassium Channels / metabolism*
-
Somatosensory Cortex / cytology
-
Somatosensory Cortex / drug effects
-
Somatosensory Cortex / physiology*
-
Time Factors
Substances
-
Elapid Venoms
-
Luminescent Proteins
-
Protein Subunits
-
Shaker Superfamily of Potassium Channels
-
dendrotoxin I