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Blood Cells Mol Dis. 2009 Mar-Apr;42(2):126-8. doi: 10.1016/j.bcmd.2008.10.007. Epub 2008 Dec 16.

Infectious proxies and childhood leukaemia: findings from the United Kingdom Childhood Cancer Study (UKCCS).

Author information

1
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK. eve.roman@egu.york.ac.uk

Abstract

The United Kingdom Childhood Cancer Study (UKCCS) was specifically designed to investigate the potential etiological role of infections as one of its objectives and information on a number of markers of infectious exposure from multiple sources was collected (www.ukccs.org). This study found that a mother's recollections of past minor illness episodes in her children were unreliable, producing systematic case-control differences. From birth onwards children diagnosed with ALL between 2-5 years were found to have had more clinically diagnosed infectious illness episodes (not fewer) than unaffected children, with those with two or more neonatal infections being diagnosed with leukaemia around 7 months earlier than those with only one or none. The findings from these analyses and their implications for future research are reviewed and discussed in this paper.

PMID:
19091606
DOI:
10.1016/j.bcmd.2008.10.007
[Indexed for MEDLINE]

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