Format

Send to

Choose Destination
Ophthalmology. 2009 Feb;116(2):297-303. doi: 10.1016/j.ophtha.2008.09.019. Epub 2008 Dec 16.

Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25.

Author information

1
National Eye Institute, Bethesda, Maryland, USA.

Abstract

PURPOSE:

To assess the risk of advanced age-related macular degeneration (AMD) developing after cataract surgery.

DESIGN:

Cohort study.

PARTICIPANTS:

Four thousand five hundred seventy-seven participants (8050 eyes) from a multicenter, controlled, randomized clinical trial, the Age-Related Eye Disease Study (AREDS).

METHODS:

Development of advanced AMD, either neovascular (NV) AMD or geographic atrophy (GA), was evaluated with annual fundus photographs, and history of cataract surgery was assessed every 6 months. Cox proportional hazard models with time-dependent covariates were conducted for NV AMD and GA separately.

MAIN OUTCOME MEASURES:

Neovascular AMD, GA, and central GA (CGA; involving the center of the macula).

RESULTS:

The Cox proportional hazards model of right eyes showed nonsignificant hazard ratios of 1.20 (95% confidence interval [CI], 0.82-1.75) for NV AMD, 0.80 (95% CI, 0.61-1.06) for GA, and 0.87 (95% CI, 0.64-1.18) for CGA. Similar results were obtained for left eyes: 1.07 (95% CI, 0.72-1.58) for NV AMD, 0.94 (95% CI, 0.71-1.25) for GA, and 0.86 (95% CI, 0.63-1.19) for CGA. For participants with advanced AMD in 1 eye (AREDS category 4), the hazard ratios for fellow eyes were 1.08 (95% CI, 0.65-1.72) for NV AMD and 0.98 (95% CI, 0.64-1.49) for CGA.

CONCLUSIONS:

The AREDS results showed no clear effect of cataract surgery on the risk of progression to advanced AMD.

FINANCIAL DISCLOSURE(S):

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

PMID:
19091420
PMCID:
PMC3021282
DOI:
10.1016/j.ophtha.2008.09.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center