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Breast Cancer Res. 2008;10 Suppl 1:S2. doi: 10.1186/bcr1988.

Mechanisms of metastasis.

Author information

1
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892-4264, USA. hunterk@mail.nih.gov

Abstract

Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex. Over the years many hypotheses were developed to try to explain the inefficiency of the metastatic process, but none of these theories completely explains the current biological and clinical observations. In this review we summarize some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression.

PMID:
19091006
PMCID:
PMC2605099
DOI:
10.1186/bcr1988
[Indexed for MEDLINE]
Free PMC Article

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