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J Infect Dis. 2009 Feb 1;199(3):445-50. doi: 10.1086/596048.

High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions.

Author information

1
National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia.

Abstract

Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-microm microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-microm constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria.

PMID:
19090777
PMCID:
PMC4337984
DOI:
10.1086/596048
[Indexed for MEDLINE]
Free PMC Article

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