Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept

Neurosci Behav Physiol. 2009 Jan;39(1):81-6. doi: 10.1007/s11055-008-9095-1. Epub 2008 Dec 17.

Abstract

Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests. C57BL/6J mice had good learning ability and memory trace retention (at 10 days) in a simplified Morris maze, while BALB/c mice had low levels of memory trace retention and DBA/2J mice had low learning ability in this test. I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no effect in DBA/2J mice. On testing the ability to extrapolate the direction of movement of a stimulus, administration of Noopept increased the proportion of correct responses in C57BL/6J and BALB/c mice, but had no effect in DBA/2J mice.

MeSH terms

  • Animals
  • Cognition / drug effects*
  • Dipeptides / pharmacology*
  • Genotype
  • Male
  • Maze Learning / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Nootropic Agents / pharmacology*
  • Species Specificity

Substances

  • Dipeptides
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly