Obestatin is a 23-amino-acid peptide encoded by the same gene as ghrelin. Because there is a paucity of data concerning the effects of exercise on obestatin, this study investigated the effect of anaerobic exercise training-detraining on obestatin and growth hormone (GH) plasma levels. Ten young female volunteers participated. Blood was collected 24 h before, and 24 h, 48 h and 7 days after the training. The data indicate that anaerobic training caused a significant reduction in GH levels but had no effect on plasma obestatin concentrations.