From immunity to tolerance through HDAC

Nat Immunol. 2009 Jan;10(1):13-4. doi: 10.1038/ni0109-13.

Abstract

Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigen-Presenting Cells / enzymology
  • Antigen-Presenting Cells / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Cytokines / biosynthesis
  • Gene Expression Regulation*
  • Histone Deacetylases / metabolism*
  • Humans
  • Immune Tolerance*
  • Interleukin-10 / genetics*
  • Promoter Regions, Genetic / physiology
  • Transcription, Genetic

Substances

  • Cytokines
  • Interleukin-10
  • HDAC11 protein, human
  • Histone Deacetylases