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Br J Cancer. 2009 Jan 13;100(1):13-8. doi: 10.1038/sj.bjc.6604822. Epub 2008 Dec 16.

Human xenograft models as useful tools to assess the potential of novel therapeutics in prostate cancer.

Author information

1
Department of Urology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands. w.vanweerden@erasmusmc.nl

Abstract

With docetaxel as effective chemotherapy for hormone refractory prostate cancer (HRPC), the number of new treatment combinations for HRPC is expanding demanding a fast-track screening system. This review elaborates on the use of xenograft models to select the most promising combination therapies for entering into phase II clinical trials.

PMID:
19088719
PMCID:
PMC2634688
DOI:
10.1038/sj.bjc.6604822
[Indexed for MEDLINE]
Free PMC Article

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