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J Gen Virol. 2009 Jan;90(Pt 1):74-8. doi: 10.1099/vir.0.005389-0.

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production.

Author information

1
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.

Abstract

The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response.

PMID:
19088275
PMCID:
PMC2956989
DOI:
10.1099/vir.0.005389-0
[Indexed for MEDLINE]
Free PMC Article

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