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Gene. 1991 Jul 15;103(1):133-4.

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

Author information

1
Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

Abstract

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

PMID:
1908809
DOI:
10.1016/0378-1119(91)90405-z
[Indexed for MEDLINE]

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