Objective: To investigate the immunoregulation action of Indian ginseng root extract (IRRE) in immunodeficiency mice.
Method: Immunodeficiency mice were fed IRRE with doses of 5, 2.5, 0.85 g x kg(-1) for 15 days before their immune function were observed.
Result: IRRE could relieve retarded growth and viscera index drop of mice induced by CP, could heighten the response of delayed hypersensitivity and the amount of antibody in serum. The proliferation of ConA-induced mitogenic response for spleen lymphocyte were also increased, compared with the CP group (P < 0.05). IRRE could enhance the content of marrow DNA and NO of serum with no change of acid phosphatase and alkalinity phosphatase.
Conclusion: IRRE could enhance the phagocytosis of celiac macrophage, protect the spleen from damage and improve marrow inhibition in immunodeficiency mice.