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Br J Neurosurg. 2008;22 Suppl 1:S41-4. doi: 10.1080/02688690802448335.

Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford.

Author information

1
Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK.

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

PMID:
19085352
DOI:
10.1080/02688690802448335
[Indexed for MEDLINE]

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