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Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1:S11-4. doi: 10.1016/j.trstmh.2008.11.002. Epub 2008 Dec 12.

The evolution of drug-resistant malaria.

Author information

1
Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD 21201, USA. cplowe@medicine.umaryland.edu

Abstract

Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, renewed efforts to eliminate and eradicate malaria will be gravely threatened. This paper, adapted from a talk given in honour of Professor Malcolm Molyneux in Liverpool in September 2008, reviews the rise and fall of clinically important forms of drug-resistant falciparum malaria and considers how lessons learned from studying the evolution of drug-resistant malaria can be applied to efforts to prevent and deter resistance.

PMID:
19084883
PMCID:
PMC2723787
DOI:
10.1016/j.trstmh.2008.11.002
[Indexed for MEDLINE]
Free PMC Article
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