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Eur J Med Chem. 2009 Jun;44(6):2731-5. doi: 10.1016/j.ejmech.2008.10.025. Epub 2008 Oct 31.

New antimalarial and cytotoxic 4-nerolidylcatechol derivatives.

Author information

1
Universidade Federal do Amazonas, Campus Universitário, 69077-000 Manaus, AM, Brazil.

Abstract

4-Nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multigram scale using straight-forward solvent extraction-column chromatography. New semi-synthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,O-dibenzoyl derivatives 2-8 exhibited IC(50) in the 0.67-22.52 microM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties.

PMID:
19084293
DOI:
10.1016/j.ejmech.2008.10.025
[Indexed for MEDLINE]

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