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Clin Biochem. 2009 May;42(7-8):736-8. doi: 10.1016/j.clinbiochem.2008.11.006. Epub 2008 Dec 3.

Unequal representation of different unique genomic DNA sequences in the cell-free plasma DNA of individual donors.

Author information

1
Department of Biological Sciences, University of Warwick, Coventry, UK.

Abstract

OBJECTIVES:

To assess whether different genomic cell-free DNAs are equally abundant in the plasma of individual donors, and any relationship between DNA methylation and representation in plasma.

DESIGN AND METHODS:

The concentrations of DNA in plasma were determined by real-time PCR.

RESULTS:

Different DNA sequences were not equally represented. The relative abundances were similar in different donors.

CONCLUSIONS:

Different DNA sequences are not equally abundant in plasma, with no relationship between DNA methylation and abundance.

[Indexed for MEDLINE]

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