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Forensic Sci Int Genet. 2008 Sep;2(4):376-8. doi: 10.1016/j.fsigen.2008.04.001. Epub 2008 May 15.

A cautionary note on the evaluation of genetic evidence from uniparentally transmitted markers.

Author information

1
IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal. aamorim@ipatimup.pt

Abstract

The combination of the information obtained from lineage genetic markers, such as mitochondrial DNA (mtDNA) and the non-homologous region of Y-chromosome, with data resulting from meiotically recombining loci (diploid/autosomal or haplodiploid/X chromosome) into a single likelihood ratio has been recently proposed. In this work we challenge this proposal and demonstrate that while the genetic evidence obtained from loci which reshuffle at meiosis is appropriate for individual probability calculations, mtDNA and Y-chromosome data are not and, consequently, that joining the evidential value of the two types of markers is generally inconsistent and should be avoided. The assumption of non-involvement of relatives must be clearly and explicitly stated and its acceptance must be left to the court decision.

PMID:
19083851
DOI:
10.1016/j.fsigen.2008.04.001
[Indexed for MEDLINE]

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