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J Bodyw Mov Ther. 2008 Jul;12(3):191-3. doi: 10.1016/j.jbmt.2008.03.005. Epub 2008 May 23.

Fibroblast mechanics in three-dimensional collagen matrices.

Author information

1
Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, USA. frederick.grinnell@utsouthwestern.edu

Abstract

Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

PMID:
19083673
PMCID:
PMC2605607
DOI:
10.1016/j.jbmt.2008.03.005
[Indexed for MEDLINE]
Free PMC Article

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