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Biomaterials. 2009 Mar;30(7):1268-72. doi: 10.1016/j.biomaterials.2008.11.012. Epub 2008 Dec 11.

The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation.

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Department of Bioengineering and Therapeutic Sciences, University of California, Box 2520, Byers Hall Rm 203C, San Francisco, CA 94158-2330, USA.


In this study we investigate the effects of nanotubular titanium oxide (TiO(2)) surfaces on vascular cells. EC and VSMC response to nanotubes was investigated through immunofluorescence staining, scanning electron microscopy, 5-ethynyl-2'-deoxyuridine proliferation assays, and prostaglandin I(2) (PGI(2)) enzyme immunoassays. We found that the nanotubular surface significantly enhances EC proliferation and secretion of PGI(2). The surface also results in a decrease in VSMC proliferation and increased expression of smooth muscle alpha-actin. These data suggest that engineered nanotopographical cues may influence both EC and VSMC behavior in a manner that may be useful for stent or other vascular applications.

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