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Arch Phys Med Rehabil. 2008 Dec;89(12 Suppl):S45-50. doi: 10.1016/j.apmr.2008.08.211.

Use of diffusion tensor imaging to examine subacute white matter injury progression in moderate to severe traumatic brain injury.

Author information

1
Department of Medical Imaging, Division of Neuroradiology, University Health Network, Toronto, ON, Canada.

Abstract

OBJECTIVE:

To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging.

DESIGN:

Prospective, repeated-measures, within-subjects design.

SETTING:

Inpatient neurorehabilitation program and teaching hospital MRI department.

PARTICIPANTS:

Brain-injured adults (N=13) with a mean Glasgow Coma Scale score of 7.67+/-4.16.

INTERVENTIONS:

Not applicable.

MAIN OUTCOME MEASURES:

Fractional anisotropy (FA) values were measured at 4.5 and 29 months postinjury in right and left frontal and temporal deep WM tracts and the anterior and posterior corpus callosum.

RESULTS:

FA significantly decreased in frontal and temporal tracts: right frontal (.38+/-.06 to .30+/-.06; P<.005), left frontal (.37+/-.06 to .32+/-.06; P<.05), right temporal (.28+/-.05 to .22+/-.018; P<.005), and left temporal (.28+/-.05 to .24+/-.02; P<.05). No significant changes were in the corpus callosum.

CONCLUSIONS:

Preliminary results demonstrate progression of WM damage as evidenced by interval changes in diffusion anisotropy. Future research should examine the relationship between decreased FA and long-term clinical outcome.

PMID:
19081441
DOI:
10.1016/j.apmr.2008.08.211
[Indexed for MEDLINE]

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