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Neuron. 2008 Dec 10;60(5):731-2. doi: 10.1016/j.neuron.2008.11.020.

A sequel to the tale of p25/Cdk5 in neurodegeneration.

Author information

1
Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

Abstract

p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.

PMID:
19081365
DOI:
10.1016/j.neuron.2008.11.020
[Indexed for MEDLINE]
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