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Nat Struct Mol Biol. 2009 Jan;16(1):89-90. doi: 10.1038/nsmb.1522. Epub 2008 Dec 14.

Crystal structure of TIPE2 provides insights into immune homeostasis.

Author information

1
Center for Structural Biology and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

Abstract

TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.

PMID:
19079267
DOI:
10.1038/nsmb.1522
[Indexed for MEDLINE]

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