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Nat Neurosci. 2009 Jan;12(1):26-8. doi: 10.1038/nn.2239. Epub 2008 Dec 14.

Developmentally degraded cortical temporal processing restored by training.

Author information

1
School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China. xmzhou@bio.ecnu.edu.cn

Abstract

Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.

PMID:
19079250
PMCID:
PMC2709597
DOI:
10.1038/nn.2239
[Indexed for MEDLINE]
Free PMC Article

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