Format

Send to

Choose Destination
Mucosal Immunol. 2008 Jan;1(1):8-10. doi: 10.1038/mi.2007.8.

Location, location, location: B-cell differentiation in the gut lamina propria.

Author information

1
Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, New York, USA. acerutti@med.cornell.edu

Abstract

The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.

PMID:
19079155
DOI:
10.1038/mi.2007.8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center