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J Invest Dermatol. 2009 Jan;129(1):7-9. doi: 10.1038/jid.2008.385.

Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk.

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1
INSERM U697, Hôpital Saint-Louis, Paris, France. alain.mauviel@inserm.fr

Abstract

In this issue, Denton et al., describe a mouse model of postnatal deletion of the transforming growth factor (TGF)-beta receptor type II (TbetaRII) in skin fibroblasts. Using a tamoxifen-dependent inducible Cre-lox strategy, the authors demonstrate the pivotal role played by TGF-beta signaling in fibroblasts during wound healing. Healing of full-thickness wounds after fibroblast-specific deletion of TbetaRII in the skin was severely impaired and exhibited delayed re-epithelialization. This study emphasizes the importance of fibroblasts in mesenchymal-epithelial interaction in the skin during wound repair.

PMID:
19078982
DOI:
10.1038/jid.2008.385
[Indexed for MEDLINE]
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