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Clin Exp Dermatol. 2009 Aug;34(6):708-10. doi: 10.1111/j.1365-2230.2008.03007.x. Epub 2008 Dec 9.

Cefuroxime-induced pemphigus erythematosus in a young boy.

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  • 1Department of Dermatology, Second University of Naples, Naples, Italy.


Pemphigus erythematosus (Senear-Usher syndrome) is a variant of superficial pemphigus with features of both lupus erythematosus and pemphigus. It affects mainly middle-aged adults, and is rarely observed before the age of 20 years. The case of a 14-year-old boy who showed cutaneous lesions suggestive for pemphigus erythematosus is described. Not all laboratory and histopathological investigations confirmed the hypothesis, so a diagnosis of clinical pemphigus erythematosus was made. Systemic steroid therapy was effective in controlling the disease. This case is interesting because of the rare occurrence of pemphigus erythematosus in adolescence and the possibility of another drug being added to the list of pemphigus inducers.

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