Abstract
Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipocytes / pathology
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Adiposity / physiology
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Cardiovascular Diseases / etiology
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Cardiovascular Diseases / prevention & control
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Diabetes Mellitus, Type 2 / etiology*
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Diabetes Mellitus, Type 2 / metabolism
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Lipid Metabolism*
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Liver / metabolism
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Muscle, Skeletal / metabolism
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Myocytes, Cardiac / metabolism
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Obesity / complications*
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Obesity / metabolism
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Thiazolidinediones / therapeutic use
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Thiazolidinediones