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Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63. doi: 10.1073/pnas.0808723105. Epub 2008 Dec 15.

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

Author information

1
The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

The intestinal epithelium is in direct contact with a vast microbiota, yet little is known about how epithelial cells defend the host against the heavy bacterial load. To address this question we studied Paneth cells, a key small intestinal epithelial lineage. We found that Paneth cells directly sense enteric bacteria through cell-autonomous MyD88-dependent toll-like receptor (TLR) activation, triggering expression of multiple antimicrobial factors. Paneth cells were essential for controlling intestinal barrier penetration by commensal and pathogenic bacteria. Furthermore, Paneth cell-intrinsic MyD88 signaling limited bacterial penetration of host tissues, revealing a role for epithelial MyD88 in maintaining intestinal homeostasis. Our findings establish that gut epithelia actively sense enteric bacteria and play an essential role in maintaining host-microbial homeostasis at the mucosal interface.

PMID:
19075245
PMCID:
PMC2603261
DOI:
10.1073/pnas.0808723105
[Indexed for MEDLINE]
Free PMC Article
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