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Angew Chem Int Ed Engl. 2009;48(10):1775-9. doi: 10.1002/anie.200804905.

A synthetic lectin for O-linked beta-N-acetylglucosamine.

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1
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

Abstract

Changing employment: Receptor 1 binds beta-N-acetylglucosaminyl (beta-GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine-O-GlcNAc posttranslational protein modification.

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PMID:
19072969
PMCID:
PMC2835298
DOI:
10.1002/anie.200804905
[Indexed for MEDLINE]
Free PMC Article

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