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Carcinogenesis. 1991 Aug;12(8):1523-5.

Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide.

Author information

1
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

Abstract

A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, was separated and identified after RNA was treated with activated 4-hydroxyaminoquinoline 1-oxide. This is the first report of a 7-arylaminated guanine adduct produced by arylaminating carcinogens.

PMID:
1907226
DOI:
10.1093/carcin/12.8.1523
[Indexed for MEDLINE]

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