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J Org Chem. 2009 Feb 6;74(3):1391-3. doi: 10.1021/jo802339t.

Polymer-immobilized catalyst for asymmetric hydrogenation of racemic alpha-(N-benzoyl-N-methylamino)propiophenone.

Author information

1
Department of Materials Science, Toyohashi University of Technology, Tempaku-cho, Toyohashi 441-8580, Japan.

Abstract

Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.

PMID:
19072091
DOI:
10.1021/jo802339t
[Indexed for MEDLINE]

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