Abstract
An increasing number of studies about the molecular basis of angiogenesis are rapidly disclosing novel signal pathways involved in the blood vessel formation process. This review will focus on bone morphogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins. These recently discovered angiogenesis mediators are involved in vascular development during embryogenesis and, interestingly, they are shared between the nervous and vascular systems. They represent new potential targets in the vasculature and suggest novel therapeutic opportunities.
MeSH terms
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Bone Morphogenetic Proteins / physiology
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Drug Delivery Systems
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Ephrins / physiology
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Hedgehog Proteins / physiology
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Humans
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Neovascularization, Pathologic / drug therapy*
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Neovascularization, Physiologic / physiology*
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Nerve Growth Factors / physiology
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Netrin-1
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Neuropilins / physiology
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Receptors, Eph Family / physiology
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Receptors, Notch / physiology
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Tumor Suppressor Proteins / physiology
Substances
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Angiogenesis Inhibitors
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Bone Morphogenetic Proteins
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Ephrins
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Hedgehog Proteins
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Nerve Growth Factors
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Neuropilins
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Receptors, Notch
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Tumor Suppressor Proteins
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Netrin-1
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Receptors, Eph Family