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Cell. 2008 Dec 12;135(6):1013-6. doi: 10.1016/j.cell.2008.11.026.

HMGA2, microRNAs, and stem cell aging.

Author information

1
Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. hammond@med.unc.edu

Abstract

Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.

PMID:
19070572
PMCID:
PMC3725266
DOI:
10.1016/j.cell.2008.11.026
[Indexed for MEDLINE]
Free PMC Article
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