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Isr Med Assoc J. 2008 Nov;10(11):816-20.

Novel therapeutic modalities in pediatric inflammatory bowel disease.

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Pediatric Gastroenterology Unit, Hadassah-Hebrew University Hospitals, Jerusalem, Israel.


Management of inflammatory bowel disease in childhood poses great challenges. Apart from the disease complications, the drugs' adverse affects, especially corticosteroids, are significant. In the past decade major progress was made in elucidating the pathogenesis of IBD, which led to new treatment options aiming to achieve better control of the disease and decrease the various complications of current therapy. In this review we provide an overview of novel therapies for IBD, their efficacy, safety and their current use in children.

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