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Neurosci Lett. 1991 Mar 11;124(1):17-21.

Contributions of low-threshold calcium current and anomalous rectifier (Ih) to slow depolarizations underlying burst firing in human neocortical neurons in vitro.

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Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163.


The slow depolarization that underlies the voltage-dependent burst-firing behavior of human neocortical neurons is mediated by a low-threshold calcium conductance in concert with the anomalous rectifier current, Ih. The slow depolarization could be elicited by depolarization from negative membrane potentials or as a rebound following hyperpolarization. The rebound depolarization was time- and voltage-dependent. Most of the slow depolarization was blocked by inorganic calcium blockers. The remainder of the depolarization and the 'sag' in the hyperpolarizing voltage responses were blocked by extracellular Cs+.

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