Abstract
Course and systematic long-term noliprel therapy of chronic obstructive lung disease (COLD) complicated by chronic pulmonary heart permitted to arrest or significantly slow down further progress of heart remodeling, impairment of systolic and diastolic function of right and left chamber and to decrease pressure in the pulmonary artery. These changes correlated with an improved clinical picture of the disease, increased tolerance to physical exercise, and reduced frequency of progressive right ventricular insufficiency. The integral indicator of clinical symptoms fell down from 12.54 +/- 0.27 to 9.26 +/- 0.22 by the 12th month of therapy. This finding confirms beneficial effect of noliprel on clinical manifestations of heart failure and substantial improvement of structural and functional parameters of the right heart.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Administration, Oral
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Adult
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use
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Diuretics / administration & dosage
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Diuretics / therapeutic use
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Dose-Response Relationship, Drug
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Drug Combinations
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Echocardiography, Doppler
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Follow-Up Studies
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Humans
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Indapamide / administration & dosage
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Indapamide / therapeutic use*
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Middle Aged
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Perindopril / administration & dosage
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Perindopril / therapeutic use*
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Pulmonary Disease, Chronic Obstructive / complications
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Pulmonary Disease, Chronic Obstructive / drug therapy*
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Pulmonary Disease, Chronic Obstructive / physiopathology
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Pulmonary Heart Disease / drug therapy*
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Pulmonary Heart Disease / etiology
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Pulmonary Heart Disease / physiopathology
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Pulmonary Wedge Pressure / drug effects
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Pulmonary Wedge Pressure / physiology
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Time Factors
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Treatment Outcome
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Ventricular Function / drug effects
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Ventricular Remodeling / physiology*
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Diuretics
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Drug Combinations
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Indapamide
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Perindopril